Advisors

Dr. Walczak is Alexander-von-Humboldt Professor at the University of Cologne, Germany, and Professor of Cancer Biology at University College London (UCL), United Kingdom. Dr. Walczak’s research focuses on the study of the functional interplay between cell death, inflammation and immunity in health and disease. His aim is to unravel the mechanisms on how different death receptor pathways, such as TRAIL-mediated apoptosis, are regulated and how they impact cancer cell survival, cancer-related inflammation and immunity. 

Dr. Stein is the Chief of the Leukemia Service, Associate Attending Physician, Clinical Investigator, and Director of the Program for Drug Development in Leukemia on the Leukemia Service at Memorial Sloan Kettering Cancer Center. He conducts novel, phase I clinical trials of drugs that target the genetic and epigenetic basis of myeloid malignancies. Dr. Stein led the clinical studies of the IDH2 inhibitor Enasidenib and the IDH1 Inhibitor Ivosidenib in patients with relapsed and refractory AML that led to their FDA approval. His current research focuses on elucidating mechanisms of resistance to IDH inhibitors and the use of Menin inhibitors in patients with MLL-rearranged acute leukemia.  He also leads a variety of phase 1 clinical trials and serves as the lead investigator at Memorial Sloan Kettering for the BEAT AML master clinical trial.

A prolific cancer drug development researcher, where he pioneered the development of apoptotic inducing TRAIL-R targeting drugs to treat cancer. He was the Vice President and Global Head of Hem-Oncology Research at Amgen where he led the development of multiple molecules including the first-in-class, bi-specific T-cell engager, Blinatumomab, and oncolytic virus Imlygic. Dr. Begley is trained as a physician and oncologist and obtained his MBBS (MD-equivalent) and PhD from University of Melbourne.